N-vinylformamide the "magic monomer" N-乙烯基甲酰胺 “神奇单体 ”

In the vast ocean of materials science, there is a compound that has attracted much attention due to its unique chemical structure and excellent performance. It is N-vinylformamide (NVF, CAS No.: 13162-05-5). Today, let us walk into the world of this magical compound.

Basic Information

N-vinylformamide is an organic compound with a molecular formula of C3H5NO and a molecular weight of 71.08. It is a colorless, transparent liquid at room temperature, has high solubility, and is miscible with water, alcohols and other solvents in any proportion. It is soluble in benzene and its derivatives. The structure of this compound contains vinyl and amide groups, which makes it less stable under acidic and alkaline conditions, but also gives it extremely high reactivity.

Synthesis Method

NVF is the simplest member of vinyl amides and is also a polymer monomer and solvent with excellent performance. Poly N-vinyl formamide (PNVF) can be obtained by free radical polymerization and other methods. Although there have been many studies on NVF compounds in the past, there have been few studies on its industrialization process. The German patent in 1966 proposed the homopolymerization technology of NVF. The British patent in 1969 introduced the copolymerization technology of NVF and ethylene monomers. The 1983 BASF patent reported the technology of preparing PNVF by homopolymerization of NVF. The industrialization of NVF was first achieved by Mitsubishi Corporation in 1992. Subsequently, companies such as Hoechst Dynapol and Celanese successively realized the industrialization of N-methyl-N-vinyl acetamide and N-vinyl acetamide. There are many methods for the synthesis of NVF, each of which has its unique advantages and applicable scenarios. With the continuous advancement of chemical technology, more efficient and environmentally friendly synthesis methods may be developed in the future to meet the growing market demand.

Application Field

■ Synthesis of polymers

N-vinylformamide is the simplest member of vinyl amides and an important monomer for synthesizing a variety of polymers. Among them, PNVF obtained by free radical polymerization is one of its most important polymerization products. PNVF has excellent solubility and gelling ability and is widely used in oilfield additives, papermaking additives, textile finishing agents and other fields. For example, in the papermaking industry, PNVF can significantly improve the strength and durability of paper.

■ Ion exchange and adsorption materials

N-vinylformamide polymers also have good ion exchange properties and can be used to prepare ion exchange resins. These resins perform well in water treatment, chemical separation and other fields, and can effectively remove heavy metal ions and organic impurities in water.

■ Biomedical materials

N-vinylformamide polymers also have important applications in the biomedical field. Due to its good biocompatibility and water absorption, it can be used to prepare drug sustained-release systems, biosensors and tissue engineering scaffolds. For example, by embedding drugs into the PNVF matrix, the slow release of drugs can be achieved and the drug's action time can be extended.

■ Coatings and Adhesives

N-vinylformamide can also be used to synthesize high-performance coatings and adhesives. Its polymers have excellent adhesion and chemical resistance, and are suitable for surface treatment of various substrates. For example, in photocurable inks and coatings, N-vinylformamide, as an active diluent, can significantly improve the curing speed and mechanical properties of coatings.

■ Pharmaceutical intermediates

In the pharmaceutical field, N-vinylformamide is an important pharmaceutical intermediate. It can be used to synthesize antibiotics, antiviral drugs, etc., providing a rich material basis for drug research and development.

■ Pesticide intermediates

In addition to the chemical and pharmaceutical fields, N-vinylformamide also shows certain application potential in the pesticide field. It can be used to synthesize pesticide intermediates such as insecticides and herbicides to help improve the activity of pesticides and reduce toxicity.

Future Outlook

With the continuous development of materials science, the application field of N-vinylformamide is still expanding. At present, the global N-vinylformamide market shows a steady growth trend, especially in Asia, where demand is growing rapidly. In the future, with the enhancement of environmental awareness and the continuous advancement of technology, the green synthesis and high-performance application of N-vinylformamide will become an important development direction.

Conclusion

As an important functional monomer, N-vinylformamide has shown great application potential in the field of materials. From polymers to biomedical materials, from coatings to adhesives, it is everywhere. With the continuous advancement of technology and the continuous growth of market demand, N-vinylformamide will play a more important role in materials science. Let us look forward to more surprises from this magical compound in the future!