Services and Solutions

品质至臻引领非凡追求卓越使命必达

One of the development trends in the chemical industry is that the safe, clean, efficient, energy saving and sustainable. Continuous flow chemistry is one of the important technologies that LinkChem supports in green chemistry. Based on industrial continuous flow reaction technology and adhering to the concept of green and safe production, it provides customers with continuous flow route design, process route optimization, laboratory testing, catalyst development, and factory feasibility studies, continuous flow equipment improvement, process development and overall equipment packaging solutions and other services to better meet customer needs for large-scale, sustainable production.

1.Process development capability

LinkChem's flow chemistry team has rich experience in process development and optimization, and has an in-depth understanding of chemical reactions and the working principles of microchannel reactors. Through perpetual innovative development and design, it can implement multi-step continuous processes for multiple products and improve society effect and economic effect, and achieve safe, green and sustainable production from laboratory to industrialization for customers.

Measurement of reaction thermodynamic and kinetic data

Development and optimization of reaction conditions

Melting crystallization technology

Photochemistry and electrochemistry

Process optimization and technology transfer

Thin film evaporation and molecular distillation

Liquid-liquid extraction and liquid-liquid two-phase separation technology

Develop process-specific control and regulatory strategies

Continuous processes such as fixed bed /trickle bed continuous hydrogenation and oxidation

Multi-step reaction continuous and integrated development of continuous extraction/separation/crystallization technology

High temperature, high pressure and ultra-low temperature continuous processes, heterogeneous continuous processes such as gas-liquid and gas-solid-liquid

Dominant Reaction Type: Nitrification reaction; Oxidation reaction; Photocatalytic reaction; Diazotization reaction; Hydrogenation reaction; Esterification reaction; Friedel-Crafts reaction; Metal reagent reaction

2.Catalyst development capability

LinkChem focuses on exploring new green synthesis methods, developing new catalyst carrier materials, and deploying a catalyst team led by PhDs. It has achieved the combination of new catalyst technology and continuous flow technology on multiple projects, achieving accelerated reaction speeds. , improve productivity, save energy and raw materials, and provide new solutions for green chemical reactions.

Catalysts prepared from proprietary mixtures or customer-specific information

Supported metal or mixed metal catalysts

Development of special metal oxide catalysts

Using commercially available support materials

Supplied by customers

Using LinkChem’ proprietary methods

Forms, shapes and sizes

Powders

Pellets

Tablets

Extrudates

Spheres

A variety of physical, chemical and mechanical characterization capabilities

3.Engineering design capability

LinkChem relies on the engineering and technical team's professional knowledge in the fields of commercial engineering management, factory equipment management and chemical process simulation, as well as many years of experience in design, to carry out engineering design according to corresponding requirements for different reaction processes:

Fast and medium speed response system

Distillation and absorption system

Selection and design of various continuous reactors

High-efficiency gas-liquid separation and solid-liquid separation engineering

Reaction and heat exchange technology between polymers and high-viscosity substances

Membrane purification technologies include tangential flow filtration (TFF), nanofiltration and pervaporation

Analytical method development and integration of process analytical technology (PAT) into continuous flow processes

Details can be found on the official website of Shanghai XFlow Chemistry

Our Discovery Services covers the entire spectrum of early-stage research from target identification to delivery of drug candidates for further development. We have experienced team of medicinal chemistry and organic chemistry experts to support our customers’ need for hit identification, lead generation lead optimization programs.
Hit identification Hit-to-lead discovery Lead generation Lead optimization SAR development Libraries synthesis for Lead compounds Patent application preparation Project management

As an experienced commercial manufacturer, LinkChem can provide one-stop outsourcing intermediates services of process route development and verification, analysis method development and verification, process improvement and application registration to help customers with investigational to commercial-scales developments. The development services include a large number of raw materials, registered starting materials and GMP advanced intermediates throughout the entire drug development process.

With our strong and diverse infrastructure, LinkChem facilities are multipurpose and flexible and allow a rapid response to meet customer requirements. LinkChem have the advantage in the field of Heterocyclic Chemistry, chiral drugs, Carbohydrate chemistry, Nucleoside chemistry, Peptide Chemistry and Antibody Drug Conjugation (ADC).

LinkChem’s factory workshop has good versatility, flexible capacity of rapid switch and project management mode to ensure that the production and operation system can quickly and high-quality delivery of products and services required by customers.

Relying on the international standard quality system and large-scale commercialized GMP product production experience, we can provide customers with high quality commercialized API and GMP intermediate products at the optimal cost, and provide customers with a series of additional services such as secondary process development and optimization. LinkChem has different types and different sizes of plants, which can achieve the perfect combination of laboratory scale to commercial production scale and ensure the stability of supply.

: Development and optimization of innovative process routes; Production of API/intermediates; Synthesis and manufacture of building blocks; Development and process optimization of preclinical candidate compounds

: Process optimization of designated routes; Production of Special chemicals; GMP/Non-GMP production of intermediates; Synthesis of high-quality kg scale samples

Service Platform: XFlow Chemistry is committed to building the flow chemistry platform using the industrial continuous flow reaction technology, adhering to the concept of green and safe production, providing customers with continuous flow process design, process optimization, laboratory testing, feasibility study, equipment improvement, process development as well as fully integrated solutions to better meet the needs of customers in large-scale, sustainable production.

Reaction Types for Flow Chemistry Applications: Nitration reaction (concentrated sulfuric acid, dichloroethane); Sulfonation reaction; Chlorination reaction (photocatalytic, thermocatalytic); Amination/Reductive amination reaction; High-temperature and high-pressure reaction; Metal reagent reaction (butyl lithium, Grignard reagent, DIBAL-H, etc.); Diazotization reaction, diazonium salt hydrolysis; Oxidation reaction (hydrogen peroxide/Swern/peroxycarboxylic acid/ozone/air/nitric acid); Esterification reaction; Azide reaction; Gas-liquid reaction

Continuous Production Technology Development: Regular products + Continuous flow process; Complete line (multi-step reaction) of continuous technology process; Continuous reaction - extraction and washing - evaporation and crystallization - distillation and concentration

New Catalyst Technology + New Reactor Technology: Application of new technologies such as solid super acids, ionic liquids + Continuous flow technology; New process + New equipment; Reduce overall costs and achieve intrinsic safety

Feasibility Assessment of Continuous Reactions: Process development and optimization; Validation and scale-up; Generation of technology packages; Technology transfer to production; Continuous process improvement; Process optimization at laboratory, kilogram and commercial production scale

LinkChem has a highly experienced regulatory affairs team which provides CMC services at all research stages of Investigational New Drug application (IND) and its clinical trial phases (P1, P2, P3), New Drug Applications (NDA), Abbreviated New Drug Application (ANDA), and post-approval regulatory services including product change, annual report and re-registration service. LinkChem establishes standardized management system to ensure the authenticity and professionalism of the data, to assist the drug regulatory department verification. With profound professional knowledge in synthesis, QC, QA, domestic and foreign policies and regulations, registration and rich industry resources, we provide domestic and foreign customers with high efficiency and high quality drug registration and declaration services in accordance with the requirements of laws and regulations.

Route Screening &process optimization of APIs

Study of complete impurities of APIs

Polymorph, salt and co-crystal screening of APIs

Crystallization processes of API and intermediate for scale-up, control of polymorph and particle size

Technical pack of intermediates support

On-site audit

IND/NDA/ANDA regular filling support

LinkChem adheres to the strategy for synchronous development in fields of pharmaceutical, new energy and advanced materials. We make the brand of LinkChem with leading service in pharmaceutical CDMO industry, and exploit the field of advanced materials relying on existing pharmaceutical business mode.

Based on rich experience in technology development and accumulation, we can provide one-stop solutions about technology R&D, key process optimization, end-product quality control and commercial manufacturing for advanced materials (photoresist monomer, PI monomer, PSPI, lithium battery additive, functional monomer, etc.) since 2015. Until now, a number of products have passed sample test, and some have been in abundant supply.

Service advantages:

Technical advantages: The company has the national CNAS recognized laboratory, obtained CNAS certificate and CMA certificate.

Team advantages: The team has been deeply engaged in the material industry for decades,
with strong independent research and development
technology capabilities.

Capacity advantages: The company's industrial bases with annual tonnage level production capacity.

Management advantages: The company has perfect quality management system, also has a wealth of industrial mass production experience.

Service scope:

Customized development

服务范围

Process research and analysis

服务范围

Commercial production services

Product list:

PI monomer，PSPI monomer，Photoresist monomer，Lithium battery additive, etc.

No.	Category	Product	CAS No.
1	PI Monomer	MCTC	[73003-90-4]
2		CBDA	[4415-87-6]
3		DMCBDA	[137820-87-2]
4		ODA	[101-80-4]
5		mTD	[84-67-3]
6		BAPB	[13080-85-8]
7		CFDA	[107934-68-9]
8		FDA	[15499-84-0]
9		N/A	[2716984-43-7]
10		N/A	[3102-70-3]
11	PSPI Monomer	BAP	[1220-78-6]
12		OBAP	[6423-17-2]
13		CHPS	[30817-90-4]
14		BAHS	[7545-50-8]
15	Photoresist Monomer	VPBO	[95418-58-9]
16	Lithium Battery Additive	VC	[872-36-6]
17	Lithium Battery Additive	LiFSI	[171611-11-3]
18	Functional Monomer	CHDA	[1076-97-7]
19		N/A	[97344-49-5]
20		N/A	[1204-10-0]
21		N/A	[128481-73-2]

: Quick analysis for new drug substance; Analytical support for process research; In process control and release test; Analytical method development, method validation and qualification; Elemental analysis and method development; Genotoxic impurity method development and validatio; Residual solvent method development and validation; Reference standard characterization and qualification; Impurity isolation, identification and characterization; Stability studies for drug substance