N-BOC-4-哌啶甲酸 明星化合物N-BOC-4-piperidinecarboxylic acidStar Compound

In the vast universe of chemistry, every compound is as unique and brilliant as a star. N-BOC-4-piperidinecarboxylic acid has become a star compound in the field of organic synthesis due to its unique structure and wide application. Today, we will explore this compound in depth.

Introduction

N-BOC-4-piperidinecarboxylic acid, also known as 1-Boc-piperidine-4-carboxylic acid or 1-tert-butyloxycarbonyl-4-piperidinecarboxylic acid, has a CAS number of 84358-13-4. N-BOC-4-piperidinecarboxylic acid has a wide range of applications in the chemical field, especially in the fields of medicine and chemical industry.

Basic Information

Synthetic Route

■ Dissolve 4-piperidinic acid in NaOH solution, slowly add BOC anhydride THF solution, and stir at room temperature for 1 hour.

■ Remove THF with a rotary evaporator, and adjust the pH value of the aqueous phase to 5-6 with dilute hydrochloric acid.

■ Extract with ethyl acetate, dry the combined organic phase with anhydrous Na2SO4 and filter.

■Concentrate the filtrate with a rotary evaporator, and obtain a white solid compound N-BOC-4-piperidinecarboxylic acid after vacuum drying.

Application Field

As an important organic compound, N-BOC-4-piperidinecarboxylic acid has wide applications in many fields.

■ Pharmaceutical field: As a pharmaceutical intermediate, N-BOC-4-piperidinecarboxylic acid has a specific chemical structure and properties that make it a key raw material for the synthesis of certain drugs. By introducing the N-BOC protecting group, the nitrogen atom on the piperidine ring can be protected to avoid unnecessary side reactions in subsequent reactions. This characteristic makes N-BOC-4-piperidinic acid have important application value in drug synthesis.

■ Chemical industry: In the chemical industry, N-BOC-4-piperidinecarboxylic acid can be used as a raw material or intermediate for the synthesis of other organic compounds and used to produce various chemicals. In addition, it can also be used to prepare certain functional materials, such as polymer materials, coatings, etc. These applications further expand the market demand and application prospects of N-BOC-4-piperidinic acid.

■Other fields: In addition to the pharmaceutical and chemical fields, N-BOC-4-piperidinecarboxylic acid can also find applications in other fields. For example, in the pesticide industry, it can be used as a raw material for synthesizing certain pesticides; in the field of liquid crystal materials, it can be used to prepare liquid crystal molecules with specific properties; in environmentally friendly materials, it can be used as an additive or modifier for certain environmentally friendly.

Conclusion

N-BOC-4-piperidinic acid plays an important role in the pharmaceutical and chemical industries with its unique chemical properties and has become an indispensable part of organic synthesis. With the continuous advancement of synthesis technology, we have reason to believe that this compound will play a greater role in future chemical research and industrial applications.